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Next, L-citrulline is recycled to re-form L-arginine, while further oxidation of NO yields endogenously produced nitrite and nitrate, some of which are stored for future use and may contribute to NOS-independent NO production ( NOS-dependent NO production is facilitated by three tissue-specific NOS isozymes, namely, nNOS, eNOS, and iNOS ( Stimulation of NO production via the NOS-dependent pathway nNOS and eNOS are calciumcalmodulin-dependent enzymes responsible for the conversion of L-arginine and oxygen to L-citrulline and NO (Tousoulis et al., 2012)

CD4(+) T-cell senescence in neurodegenerative disease: pathogenesis and potential therapeutic targets

The extrinsic way contains various signaling proteins, such as death receptors and ligands, APO-1/Fas (CD95), tumor necrosis factor-alpha (TNF-)/TNFR1, Apo3L/DR3, Apo2L/DR4, and Apo2L/DR5 that are parts of the TNF gene superfamily

doi: 10.1016/j.etap.2016.06.008