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Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation

doi: 10.1146/annurev-micro-091014-104330 59 NoverrM

MW, HW, and YLu were involved in the cell culture and in vitro experiments

Using a multi-omics approach, we examined the outcomes of independently knocking down 438 antioxidative stress genes by analysing the Broad Institutes Project Achilles dataset (genome-wide shRNA knockdown in 201 cancer cell lines 16 ) (see Methods)