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First-Pass Metabolism: Nutrients travel to the liver, where enzymes may modify or eliminate them before they reach circulation

De Miguel-Bonet MDM, Ahad S, Hartenstein V., "Role of neoblasts in the patterned postembryonic growth of the platyhelminth Macrostomum lignano", Neurogenesis 5: 1-9 (2018)

When enzyme induction is achieved, the pharmacological effects of a specific drug may be reduced, since not only the metabolism of rifampicin itself, but also the metabolism of the other drug is accelerated The problem arises when doses are increased to reduce the effects of the combined drugs: increased serum concentrations of the combined drugs may possibly produce adverse effect because of the lost enzyme induction if rifampicin is discontinued

Patients should follow the dosing instructions on the ibuprofen packaging or as advised by their healthcare provider, and should not exceed recommended doses or duration of use without medical guidance