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and immune surveillance.1, 5 Hepatocytes have an eosinophilic cytoplasm reflecting numerous mitochondria, and basophilic stippling caused by large amounts of rough endoplasmic reticulum and free ribosomes

Mutations in the gene coding for the protein superoxide dismutase 1 (SOD1) were among the first identified as being involved in ALS

They have been shown to redistribute heavy metals from other tissues to the brain, increasing brain neurotoxicity and leading to the loss of essential metals, such as zinc, or even hepatotoxicity due to serious side effects due to hepatotoxicity (134)

Wilmer MJ, Emma F, Levtchenko EN (2010) The pathogenesis of cystinosis: mechanisms beyond cystine accumulation