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In Wistar rats with ISO-induced MI, they found increased oxidative stress due to the fact of ROS and also an increase in MDA levels which led to a decrease in antioxidant levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), dysregulated lipid metabolism, and inflammation due to an increase in reactive nitrogen species

Long-term clinical outcome of patients with metastatic melanoma and initial stable disease during anti-PD-1 checkpoint inhibitor immunotherapy with pembrolizumab

In addition, silibinin-loaded PLGA nanoparticles alleviate dacarbazine (DTIC)-induced hepatotoxicity in a melanoma mouse model by lowering liver enzyme and bilirubin levels and upregulating detoxification enzymes like NQO1 and GSTP1 [884]