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Notably, the PCSK9 inhibition, by either the gene manipulation or anti-PCSK9 monoclonal antibodies, has been found to significantly attenuate ROS-mediated oxidative damage in the in vitro cellular model [45, 46] and various animal models [47, 48]

Li B, Wang Z, Hong J, Che Y, Chen R, Hu Z, et al

Furthermore, isolated MSCs undergo an age-dependent functional decline in stemness and undergo intrinsic alterations during in vitro culture, which also reduces their functions [9, 10]