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Description

Pyruvate dehydrogenase complex deficiency results in impaired conversion of pyruvate to acetyl-CoA, reduced production of citrate, and, therefore, impairment of the TCA cycle, leading to severe energy deficits (especially in the CNS)

However, because of the methodological complexity associated to realtime, patiotemporal measurements of formaldehyde in living cells and tissues, these effects have been barely deciphered