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Phase I study of 6-diazo-5-oxo-L-norleucine (DON)

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Disclosures: Takeshi Chida: The Chemo-Sero-Therapeutic Research Institute: Grant/Research Support, Masahiko Ito: Nothing to Disclose, Kazuyoshi Ohta: Nothing to Disclose, Hidenao Noritake: Nothing to Disclose, Kazuhito Kawata: Nothing to Disclose, Tetsuro Suzuki: Nothing to Disclose 511 DIRECTLY OBSERVED DAA THERAPY COMPRISING EXTENDED DISPENSATION INTERVALS AS A UNIQUE APPROACH TO STREAMLINED HCV MICROELIMINATION FOR PWID Caroline Schwarz 1 Angelika Schtz 2 David Bauer 1 Enisa Gutic 1 Thomas Reiberger 3 Hans Haltmayer 2 Michael Gschwantler 1 , 1 Klinik Ottakring, Vienna, Austria, 2 Suchthilfe Wien gGmbH, Vienna, Austria, 3 Medical University of Vienna Background: Directly observed therapy (DOT) with direct-acting antivirals (DAA) alongside opioid agonist therapy (OAT) is an effective hepatitis C (HCV) microelimination strategy for people who inject drugs (PWID)