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Abbreviations CKD chronic kidney disease CMAH cytidine monophospho- N -acetylneuraminic acid hydroxylase CVD cardiovascular disease FMO3 flavin monooxygenase 3 GM3 monosialodihexosylganglioside HCAs heterocyclic amines Neu5Ac N -acetylneuraminic acid Neu5Gc N -glycolylneuraminic acid NOCs N-nitroso compounds PAHs polycyclic aromatic hydrocarbons TGF- transforming growth factor beta TMA trimethylamine TMAO trimethylamineN-oxide WHO-IARC World Health Organization-International Agency for Research on Cancer Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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Symptoms of severe Melaena include light-headedness, weakness, or fainting, and should be treated as a medical emergency