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Adverse Effects of First-Generation Antipsychotics Possible side effects and adverse effects of first-generation antipsychotics include (1, 2, 5, 6, 7, 8): Extrapyramidal symptoms, which are drug-induced movement disorders, such as: Akathisia Dystonia Dyskinesia Akinesia Muscle stiffness Tardive dyskinesia Anticholinergic effects such as: Constipation Urinary retention Blurred vision Sedation Confusion Drowsiness Dizziness Headache Agitation Seizure Cerebral edema Peripheral edema Impaired regulation of body temperature Hypotension Orthostatic hypotension Abnormal ECG results or cardiac abnormalities Retinal disorders such as: Pigmentary retinopathy Retinitis pigmentosa Nausea Diarrhea Hypersensitivity reactions such as: Rash Pruritus (itching) Light sensitivity Abnormal liver function test results Sexual dysfunction Neurological Effects First-generation antipsychotics are associated with significant extrapyramidal (EPS) side effects

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