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Further, Gpx4-deficient Tregs can contribute to ferroptosis upon T cell receptor (TCR)/CD28 co-stimulation, thus weakening immune tolerance [38]

These findings imply a significant positive effect with age and accelerate inflammation: following the step of initial dysbiosis and inflammation cascade, the altered GM and persistence of inflammation may act synergistically, prolonging the proinflammatory status

rebaudiana and its related species, comprehensive global studies comparing their chemical profiles and pharmacological activities are urgently needed to elucidate the functional relationships among species and to recognize optimal selection strategies (Yi et al., 2012)