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Proc Natl Acad Sci USA 95:1171511720 Cheng G, Zielonka J, McAllister DM et al (2013) Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

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However, the advantage of scavengers over enzymatic antioxidants is their small size, which allows them to diffuse through cell membranes and localize near biological molecules which are potential targets of ROS (Kohen and Nyska, 2002)