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The evidence for some B vitamins is stronger than it is for others

Figure 2 5 Antioxidant potential of the ketogenic diet The skin is the largest organ of the human body, one that is particularly susceptible to oxidative stress because of its constant exposure to external factors (106, 107)

It may act by (i) suppressing cyclooxygenase-2 (COX-2), an enzyme involved in VEGF production, and (ii) preventing the activation of HIF-1, the primary stimulator of VEGF expression 44

In a normal digestive process in the stomach, hydrochloric acid helps release B12 from food, and the food carrier proteins let the B12 bind to haptocorrin