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University of Navarra, 4 Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, 5 Experimenal Hepatology and Drug Targeting Group, Institute of Biomedical Research of Salamanca, 6 Liver Disease Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 7 Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country Background: Cholangiocarcinoma (CCA) includes a diverse range of biliary malignant tumours characterized by dismal prognosis

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Higher concentrations (3%+) are best reserved for experienced users or targeted use, as they raise the risk of irritation and staining without clearly proportional benefits

Tumor necrosis factor-: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head