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They have received extensive attention for their antioxidant, anti-inflammatory, anti-mutagenic and anti-cancer properties, as well as their ability to protect against cardiovascular disease [122]

Peer review Peer review information Nature Communications thanks Rajesh Katare, Boyi Gan, Lu Cai and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

An alteration in the metabolism of Met which results in HHcy is associated with risk for vascular disease as well as several other age-related pathologies

For example, the mitophagy inducer Urolithin A prevented ARHL in mice by enhancing the clearance of damaged mitochondria and improving mitochondrial DNA integrity and ATP production in the auditory system (Cho et al., 2024)