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Cyanocobalamin 50 mcg Tablets Summary of Product Characteristics

The full list of all the identified targets is available in Supplementary File 1

Addition of PRT062607 leads to a reduction of the pUb signal in a dose-dependent manner, as well as inhibition of Mfn2 ubiquitination

Mechanistically, these protective effects can be attributed to diminished SMC necroptosis which leads to reduction in the release of proinflammatory cytokines and DAMPs [11] via rapid permeabilization of the cell membranes as well as preventing release of inflammatory mediators activating pattern recognition receptors (PPRs) on neutrophils and macrophages [39]