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This is especially relevant if you are supplementing B6 from multiple sources or if you have risk factors for B6 deficiency or toxicity

3.5 FXR-TonEBP axis was enhanced after water deprivation challenge in a normal state, but this compensatory protective response blunted in DM Immunofluorescence analysis revealed that water deprivation significantly increased FXR expression in the control water deprivation group, whereas this upregulation was less pronounced in the DM water deprivation group (Figure 4A,C)

Furthermore, initiation of treatment at a later time would mean that the untreated (control) mice would have too big a tumour burden to survive the duration of the experiment (a situation unacceptable to our Animal Ethics Committee)

ALZET Osmotic Pumps, CA, USA) that were surgically placed subcutaneously between the scapulae