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10.3390/ijms26010303 494 RajasekarK.MuntahaS

Interaction of cupric ions (Cu 2+ ) with superoxide radical anion (O 2 - ) or reducing agents like ascorbic acid (AscH - ) or glutathione (GSH) results in the formation of cuprous species Cu + Cuprous ions can catalyze the production of hydroxyl radicals from hydrogen peroxide through the Fenton reaction (Haber-Weiss mechanism) (Bremner, 1993[49]) The hydroxyl radical exhibits a high degree of reactivity, enabling it to interact with nearly all biological molecules in close proximity through the hydrogen abstraction mechanism, which results in the formation of carbon-centered radicals, such as lipid radicals derived from unsaturated fatty acids

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