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On day 8, the mean tumor diameters reached 2 mm, and the mice were randomly divided into 4 groups for injections ( n = 6)

To elucidate the molecular origin of the 5-nitroimidazole ether activity switch, we solved high-resolution X-ray structures of monomeric HpTpx and in complex with both ligands (see Supplementary Section 1 for detailed structural information)