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doi: 10.1080/16078454.2019.1687144 2 KimSM

L-glutathione The Master Antioxidant, Delivered Supports: liver, kidneys, mitochondria Specializes In: PFAS, heavy metals, oxidized pesticide metabolites, aldehydes Why it matters: pets cant keep up with GSH loss from constant airborne and dietary insult Carnosine The AGE Breaker Supports: kidneys, vasculature, collagen, metabolic stress Specializes In: carbonyl toxins, glycation end-products Why it matters: pets eating heat-processed diets and treats ingest 122 higher AGEs than humans Carnosine binds AGE carbonyls before they enter the bloodstream, preventing collagen stiffening, kidney aging, and vascular injury from diet-borne glycotoxins

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Beyond anti-inflammatory effects, these compounds exert multi-dimensional benefits: enhancement of antioxidant defenses (vitamin E and D, curcumin), promotion of anti-inflammatory macrophage polarization (VD, DHA), direct inhibition of hepatic stellate cell activation and fibrogenesis (DHA, VD, curcumin), and improvement of metabolic parameters, including insulin sensitivity