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However, patients who underwent unplanned elective operations are not by definition more at risk than those undergoing colo/ileostomy reversals

This is because these methods allow the optimization of several design and development processes (4) In this regard, some recent examples of these developments about the solubility prediction of drugs are described in the literature as follows: in neat water (9), in simulated gastrointestinal fluids (10), in organic solvents (11) and in mixed solvents (12-14)

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