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This is made possible through a legal document that transfers title to a third party, typically a Trustee, who has the authority to enforce the terms of the agreement if necessary

Conceptually however, EAE presupposes that MS is also driven by a primary autoimmune attack originating in the periphery, and if this assumption proves incorrect, then this model may be fundamentally misleading with respect to the true etiology of MS

This makes it uniquely valuable for researchers studying comprehensive metabolic regulation, allowing investigation of both incretin-dependent and incretin-independent appetite control mechanisms in a single model

J., Kang-Mieler J