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In Pgam5 -deleted mice, it counterproductively promoted mitochondrial fusion, leading to intracellular ROS accumulation as well as oxidative stress, thus accelerating RPE cell senescence, in which the IRF/IFN- pathway was also observed, which may be related to cell senescence

Confocal images were acquired with 405 nm laser/418495 nm filter and 488 nm laser/499615 nm filter

In addition to transnitrosation, a slower reaction between an S-nitrosothiol and a thiol has been reported that results in the formation of glutathione disulfide (GSSG) and lower oxides of nitrogen (nitrous oxide, ammonia, hydroxylamine as well as sulfinamides) [9,30,31]