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AMPK is known to play a role in the treatment of obesity and metabolic disorders by inhibiting anabolic pathways and enhancing catabolic pathways [36]

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Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor- (TNF-), along with hypoxic stress, oxidative damage, and uremic toxins, have been shown to suppress the expression and activity of CYP27B1 through multiple signaling pathways, resulting in reduced synthesis of 1,25(OH)D ( In addition to hydroxylase dysregulation, another critical barrier to effective vitamin D signaling in CKD lies in the impaired stability of the VDR

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As shown in the Figure above, at the end of a month, weekly nasal administration results in significantly higher serum Vitamin B12 levels than after intramuscular administration

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