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The melanin relative content and intracellular tyrosinase activity decreased in a very distinct and dose-dependent way by the studied substance

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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD