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At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days

Moreover, the saline + Laser and PDA@Pt + Laser groups underwent intra-articular injection of saline and PDA@Pt, respectively, into the joints of acute gout rats

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