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However, in yeast with LD deficiency, similar autophagy defects cannot be reversed by FFAs, indicating that LDs alone, and not the decomposition of FFAs, are important

Phase 2b studies demonstrated tirzepatide produces HbA1c reductions of up to 2.4% versus placebo at 26 weeks (Thomas et al., 2021), with Phase 3 SURPASS trials confirming mean HbA1c reductions from baseline of 2.07 percentage points with tirzepatide 15 mg (treatment difference vs