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Indeed, excessive ROS disrupt the BBB integrity, impairing its selective permeability (Hu et al., 2020)

SLC7A11 deficiency accelerates the progression of high-fat diet-induced MASLD through ferroptosis induced by classical cystine/cysteine deficiency, while serine deficiency and consequent obstruction of de novo synthesis of cysteine are responsible for the progression of ferroptosis induced MAFLD in hepatic SLC7A11 overexpressing mice

DNA methylation usually results in the silencing of genes, whereas demethylation leads to gene activation