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The ZIPs are typically synthesized on ribosomes attached to the endoplasmic reticulum (ER) and later transported to various intracellular compartments

Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T (2017) Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS

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Additionally there are studies showing an association between HHcy and osteoporosis [69], end stage renal disease (ESRD) [70], insulin resistance (IR) [71, 72], aneurysm [73,74,75], hypothyroidism [76, 77] cancer [78, 79] and gastrointestinal disorders [80] to mention some