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Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection

Notably, Hrg1 is genetically located upstream of HMOX1 and Fpn1 , and directly regulates the EP process, further enhancing the complexity of the EP regulatory network (92)

K.MishraS.MazumderR.DeshmukhR.RahmanA

Cystine starvation has been shown to impede TNBC growth, which affects stem cell properties and chemotherapy resistance in TNBC (27), thereby promoting TNBC cell ferroptosis through activation of the general control nonderepessible 2-eukaryotic translation initiation factor 2 subunit 1-activating transcription factor 4-CHAC1 pathway through the specific cytosolic GSH degradation enzyme CHAC1 (28)