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Suppression of IL-10/STAT3 or TGF-/SMAD-dependent antioxidant circuits enables the restoration of lipid peroxidation susceptibility in adjacent tumor cells (107)

In the pathogenesis of PD, regulation of the glutamate transporter gene is considered to be affected by epigenetic modifications

It is supposed to enter the TCA cycle as acetyl coenzyme A (AcCoA) after the oxidative decarboxylation by pyruvate dehydrogenase in normal metabolic status [60], but it turns out to be priorly transferred into LA in cancer cells and then shuttled to adjacent cells or stroma [61]

The mechanisms through which Vit.E suppresses NF-B activation likely pertain to its antioxidative properties