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Furthermore, Nano-HBOCs have broad application prospects (Table 2), and have attracted increasing attention from the medical, material, chemical, biological, and engineering research attention

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2 The intrinsic resistance is mediated by the inherent or endogenous characteristics that are exist in tumor cells or tissues prior to initial treatment, such as effective DNA damage repair mechanisms, tumor growth kinetics and stem cell like properties, that offer cancer cells survival benefits and ability to adapt to primary therapeutic stress

Animal studies have also shown reduced tumor growth and metastasis in various cancer models