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Statistical analysis was performed with Stat View 4.5 software (Abacus Corporation, Baltimore, USA) for Windows, the data were analyzed using one-way ANOVA followed by Fishers protected least significance difference [PLSD] post hoc test

-KG, also named 2-oxoglutarate, is a cofactor for 2-oxoglutarate-dependent dioxygenases (2-OGDDs), which catalyze hydroxylation reactions on diverse substrates