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It requires sterile technique, causes discomfort for needle-averse individuals, creates potential injection site reactions, and demands careful rotation to avoid tissue damage over extended protocols

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This translocation of the luminal contents into the lamina propria persistently stimulates the immune system leading to its hyper-activation and eventual damage to the intestine

This is an interesting finding, as it indicates that changes in lipid metabolism are occurring in the occipital cortex, although this is a brain region which is spared in PD, including the absence of Lewy bodies