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Gaur P, Sepesi B, Hofstetter WL, Correa AM, Bhutani MS, Ajani JA, Erasmus J, Komaki R, Lee JHL, Maru D, Mehran R, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Peters JH, Watson TJ, Swisher SG

The Bottom Line: Compelling Mechanisms Demand Rigorous Human Investigation BPC-157 presents a fascinating scientific paradox: extensive preclinical evidence spanning three decades demonstrates pleiotropic effects across multiple neurotransmitter systems, with antidepressant efficacy exceeding standard drugs in animal models, anxiolytic effects without dependence liability, neuroprotection in stroke and neurodegeneration models, and reversal of schizophrenia-like cognitive deficits

Whether or not the potential confounders were removed, the MR analysis of the 2 showed no significant statistical differences

Enthusiasm for nutrient antioxidants has been fueled by observations that ocular levels of ascorbate are related to dietary intake in humans and animals that require exogenous ascorbate (see Fig