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This promotes the therapeutic view of regulating systemic immunity by manipulating the intestinal microbiota community either through stimulating bacterial growth via supplementation with prebiotics (non-viable bacterial components and metabolites) or through expansion via administration of probiotics (live beneficial gut bacteria) and synbiotics (combinations of probiotics and prebiotics) (see Table 3)

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Glucose homeostasis is primarily regulated by insulin, which lowers blood glucose by increasing the uptake into cells and increasing its utilization and storage as fat and glycogen in peripheral tissues