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The large UK Caucasian HT case control cohort study demonstrated clear differences in association within the HLA class II region between Hashimoto's thyroiditis and Graves' disease, differences in HLA class II genotype may, in part, contribute to the different immunopathological processes and clinical presentation of these related diseases (15a)

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Mutations in KRAS lead to the upregulation of the expression of the SLC7A5, SLC38A2, and SLC25A22 transporters in cancer cells, thereby promoting glutamine uptake [50]