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In terms of diet, humans and other animals must consume protein to meet needs for amino acids including specific amino acids that cannot be synthesized by the organism

The sensitivity and variability of pyruvate dehydrogenase complex activity testing using cultured fibroblasts, WBC lymphocytes, or skeletal muscle tissue for other pyruvate dehydrogenase complex deficiency-associated genes remain to be thoroughly evaluated

Chang X, Liu X, Wang X, Ma L, Liang J, Li Y

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