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These hurdles include: incentives for protecting and publishing small sample studies necessary for career advancement of scientists, image processing almost always unique to each laboratory, symptom fluctuations over time not captured by single imaging timepoints, heterogeneity within patient samples, lack of mechanistic understanding of treatments, lack of symptom-relevant experimental tasks/contexts, and other factors

V., Rajasekharan, K

In addition to this molecular regulation, pharmacokinetics is also influenced by circadian variation in physiological processes such as hepatic blood flow, gastrointestinal motility, gastric pH, renal perfusion, and plasma concentration of binding proteins, which vary rhythmically and interfere with the absorption, availability, metabolism, and excretion of drugs

U., Fehr J