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By contrast, deep-learning-based generative models can now interrogate large chemical-biological datasets to uncover structure-activity relationships, generating novel scaffolds with plausible three-dimensional conformations and tailored engagement of both target and E3 ligase, thereby vastly expanding accessible chemical space [62, 282,283,284,285,286,287]

As GABA is known to have a significant and conserved function in regulating sleep, GABAergic tone should be strictly regulated in sleep circuits

Like chaperone heat shock proteins (HSP), The molecular mass of HSPs ranges from 10 to 200 KD (kilo Daltons)