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This is a broad preclinical portfolio and every item in it uses a route or model that has not been replicated in human subjects

Ketamine for Intractable Headache Chronic refractory headache, defined as headache that causes significant impairment or disability and does not respond adequately to multiple acute and preventive treatments, is among the greatest challenges in clinical practice

In vivo, nAbs can mediate antiviral functions through several mechanisms, including neutralization, which is defined by in vitro assays in which nAbs block viral entry to target cells, and antibody effector functions, which are defined by in vitro assays that evaluate nAbs against viruses and infected cells in the presence of effector systems

Oral supplements may appear cheaper per unit but require significantly higher doses, which can offset the initial cost advantage