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Furthermore, it is possible that somatostatin directly inhibits glucagon secretion by binding to its receptor in the alpha cell, since GLP- 1 stimulates islet somatostatin secretion directly through the canonical GLP- 1 receptor, expressed on delta cells [71]

The risk, however, follows a temporal pattern: 4050% of patients with high-risk alcohol use before surgery reduced drinking within the first postoperative year (233, 255257), but AUD incidence rises sharply two or more years later (233, 258, 259)