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Key Points Aberrant c-MET pathway activation occurs frequently in gastrointestinal tumours and can result from multiple mechanisms, including c-MET protein overexpression, MET amplification or enhanced transcription and/or aberrant autocrine or paracrine secretion of HGF Activated c-MET signalling results in enhanced cancer cell proliferation, survival and invasion

Its mechanism involves stimulating natural GH release specifically to reduce visceral adipose tissue, with research originally focused on HIV-associated lipodystrophy

19 , 2026 DDaniil Andreev26 , 2026 30

However, LOsG impaired glucose tolerances (GT), as revealed by OGTT and decreased fast plasma insulin level (Fig