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Note that uncontrollable is one of the key defining characteristics of RLS, along with the tingling, itching, and pins-and-needles sensations in the legs

In fact, the rationale for their use was the promising evidence from trials in other neurological diseases, rather than mechanistic information to support their use in SCA3

Noradrenaline and dopamine belong to neuromediators participating in regulation of alertness, arousal, locomotor activity, learning and memory (206, 232) and are presumed to have a significant impact on the aforementioned observations

As the solution contains 0.9% benzyl alcohol as a bacteriostatic preservative, the risk of microbial contamination in the vials is minimal