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The activation of these inflammatory pathways is often accompanied by increased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), further promoting liver injury (Vangaveti et al

Accordingly, for clinical-stage PROTACs, selectivity is more appropriately understood primarily at the levels of target engagement and degradation profile, whereas strict cell-type selectivity is not generally considered an intrinsic property

Additionally, NPs can release medications for a prolonged period, ensuring targeted delivery to specific tissues

GABAa receptors can become desensitized to GABA and stop opening when the ligand is attached