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& Hynes, J

Our optimized protocol balances damage from osmotic changes of cell volume due to transmembrane solute-solvent flux during concentration changes of CPA with the temperature- and time-dependent toxicity of higher CPA concentrations ( 40, 41 )

The arrows show vacuolization in the myelin sheath, the arrowheads indicate Schwann cells, and asterisks indicate myelin sheath disarrangement in the nerve fibers