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2022 Although N isoforms can also act as dominant-negative inhibitors of the full-length proteins and promote tumorigenesis in cells containing wild-type p53 and TAp73 13 in contrast to p53, mice lacking p73 show no increased susceptibility to spontaneous tumorigenesis

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Preclinical studies in rodent models have examined its interactions with nitric oxide signaling, angiogenic factors including VEGF, fibroblast migration, and collagen synthesis in various tissue types