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Relevant to the studies presented here, at one-month of age -synuclein transgenic mice (SWT+/+) exhibit increased numbers of activated microglia in the SNpc as well as increased expression of TNF in the SN and striatum, demonstrating an early microglial activation driven by the overexpression of -synuclein (Su et al

In contrast, synthetic anabolicandrogenic derivatives used in non-medical settings are chemically modified to resist hepatic metabolism, thereby prolonging androgen receptor activation and increasing the risk of hepatotoxic accumulation (74)

This combination often leads to smoother texture and more even-looking colour over time

[4] Baldwin, W