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Although our observations would be consistent with a model whereby repletion of the NAD(P) + metabolome could provide a buffer to replenish NADPH levels in the ovary, further work will be needed to determine the extent to which these systems are relevant to the protection against ovarian dysfunction and infertility

Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jkel O, Mohan R , Titt U, Grosshans DR

These include eyelid edema, conjunctival congestion, corneal abrasions, optic neuropathy, ptosis, purulent ocular secretions, conjunctival and episcleral hyperemia, symblepharon, macular retinal striae, ciliary congestion, corneal edema with Descemets membrane folding, and even vision loss

Transduced CAOV3 cells were selected with 1 g/mL of puromycin (Sigma, P8833) for at least 4 days