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This can lead to intestinal permeability which is often a trigger for autoimmune disorders if not addressed

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Indeed, glutamine-derived R-2-HG accumulates and prevents the differentiation of myeloblasts, resulting in uncontrolled growth of blood cells 122

To elucidate the potential mechanisms underlying this protection phenotype, we adopted a chemical genetic approach by conducting a focused compound screen that included compounds targeting ferroptosis-related pathways